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2cry
From Proteopedia
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==Solution structure of the fifth ig-like domain of human kin of IRRE like 3== | ==Solution structure of the fifth ig-like domain of human kin of IRRE like 3== | ||
| - | <StructureSection load='2cry' size='340' side='right' caption='[[2cry | + | <StructureSection load='2cry' size='340' side='right'caption='[[2cry]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cry]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2cry]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CRY FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cry OCA], [https://pdbe.org/2cry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cry RCSB], [https://www.ebi.ac.uk/pdbsum/2cry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cry ProSAT], [https://www.topsan.org/Proteins/RSGI/2cry TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KIRR3_HUMAN KIRR3_HUMAN] Note=A chromosomal aberration involving KIRREL3 and CDH15 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in KIRREL3 are the cause of mental retardation autosomal dominant type 4 (MRD4) [MIM:[https://omim.org/entry/612581 612581]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:19012874</ref> |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KIRR3_HUMAN KIRR3_HUMAN] Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Hayashi F]] |
| - | [[Category: | + | [[Category: Kurosaki C]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
| - | [[Category: Yoshida | + | [[Category: Yoshida M]] |
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Current revision
Solution structure of the fifth ig-like domain of human kin of IRRE like 3
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