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5zoj

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'''Unreleased structure'''
 
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The entry 5zoj is ON HOLD until Paper Publication
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==Crystal structure of human SMAD2-MAN1 complex==
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<StructureSection load='5zoj' size='340' side='right'caption='[[5zoj]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5zoj]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZOJ FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.794&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zoj OCA], [https://pdbe.org/5zoj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zoj RCSB], [https://www.ebi.ac.uk/pdbsum/5zoj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zoj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SMAD2_HUMAN SMAD2_HUMAN] Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.<ref>PMID:9892009</ref> <ref>PMID:16751101</ref> <ref>PMID:17327236</ref> <ref>PMID:16862174</ref> <ref>PMID:19289081</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ito T]]
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[[Category: Miyazono K]]
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[[Category: Ohno Y]]
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[[Category: Tanokura M]]

Current revision

Crystal structure of human SMAD2-MAN1 complex

PDB ID 5zoj

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OCA

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