This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6gko
From Proteopedia
(Difference between revisions)
m (Protected "6gko" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Mouse thymidylate synthase cocrystallized with dUMP and soaked in phenolphthalein== | |
| - | + | <StructureSection load='6gko' size='340' side='right'caption='[[6gko]], [[Resolution|resolution]] 1.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6gko]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GKO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GKO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FGT:3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one'>FGT</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gko OCA], [http://pdbe.org/6gko PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gko RCSB], [http://www.ebi.ac.uk/pdbsum/6gko PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gko ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TYSY_MOUSE TYSY_MOUSE]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thymidylate synthase]] | ||
[[Category: Jarmula, A]] | [[Category: Jarmula, A]] | ||
[[Category: Maj, P]] | [[Category: Maj, P]] | ||
| - | [[Category: Weiss, M | + | [[Category: Rode, W]] |
| + | [[Category: Weiss, M S]] | ||
| + | [[Category: Wilk, P]] | ||
| + | [[Category: Fragment]] | ||
| + | [[Category: Fragment screening]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Transferase]] | ||
Current revision
Mouse thymidylate synthase cocrystallized with dUMP and soaked in phenolphthalein
| |||||||||||
