|
|
| (7 intermediate revisions not shown.) |
| Line 1: |
Line 1: |
| - | [[Image:2ipy.gif|left|200px]] | + | #REDIRECT [[3snp]] This PDB entry is obsolete and replaced by 3snp |
| - | | + | |
| - | {{Structure
| + | |
| - | |PDB= 2ipy |SIZE=350|CAPTION= <scene name='initialview01'>2ipy</scene>, resolution 2.80Å
| + | |
| - | |SITE=
| + | |
| - | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene>
| + | |
| - | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span>
| + | |
| - | |GENE=
| + | |
| - | |DOMAIN=
| + | |
| - | |RELATEDENTRY=
| + | |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ipy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipy OCA], [http://www.ebi.ac.uk/pdbsum/2ipy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ipy RCSB]</span>
| + | |
| - | }}
| + | |
| - | | + | |
| - | '''crystal structure of iron regulatory protein 1 in complex with ferritin H IRE-RNA'''
| + | |
| - | | + | |
| - | | + | |
| - | ==Overview==
| + | |
| - | Iron regulatory protein 1 (IRP1) binds iron-responsive elements (IREs) in messenger RNAs (mRNAs), to repress translation or degradation, or binds an iron-sulfur cluster, to become a cytosolic aconitase enzyme. The 2.8 angstrom resolution crystal structure of the IRP1:ferritin H IRE complex shows an open protein conformation compared with that of cytosolic aconitase. The extended, L-shaped IRP1 molecule embraces the IRE stem-loop through interactions at two sites separated by approximately 30 angstroms, each involving about a dozen protein:RNA bonds. Extensive conformational changes related to binding the IRE or an iron-sulfur cluster explain the alternate functions of IRP1 as an mRNA regulator or enzyme.
| + | |
| - | | + | |
| - | ==About this Structure==
| + | |
| - | 2IPY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. The following page contains interesting information on the relation of 2IPY with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb89_1.html Aconitase and Iron Regulatory Protein 1]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPY OCA].
| + | |
| - | | + | |
| - | ==Reference==
| + | |
| - | Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA., Walden WE, Selezneva AI, Dupuy J, Volbeda A, Fontecilla-Camps JC, Theil EC, Volz K, Science. 2006 Dec 22;314(5807):1903-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17185597 17185597]
| + | |
| - | [[Category: Aconitase and Iron Regulatory Protein 1]]
| + | |
| - | [[Category: Aconitate hydratase]]
| + | |
| - | [[Category: Oryctolagus cuniculus]]
| + | |
| - | [[Category: Single protein]]
| + | |
| - | [[Category: Dupuy, J.]]
| + | |
| - | [[Category: Fontecilla-Camps, J C.]]
| + | |
| - | [[Category: Selezneva, A I.]]
| + | |
| - | [[Category: Theil, E C.]]
| + | |
| - | [[Category: Volbeda, A.]]
| + | |
| - | [[Category: Volz, K.]]
| + | |
| - | [[Category: Walden, W E.]]
| + | |
| - | [[Category: protein-rna complex]]
| + | |
| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:47:19 2008''
| + | |
