6glq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 6glq is ON HOLD Authors: Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A. Description: hMTH1 N33G in complex with LW14. [[Category: Unreleased St...)
Current revision (05:16, 21 November 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6glq is ON HOLD
+
==Crystal structure of hMTH1 N33G in complex with LW14 in the absence of acetate==
 +
<StructureSection load='6glq' size='340' side='right'caption='[[6glq]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[6glq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GLQ FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.601&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU8:1~{H}-imidazo[4,5-b]pyridin-2-amine'>BU8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6glq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6glq OCA], [https://pdbe.org/6glq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6glq RCSB], [https://www.ebi.ac.uk/pdbsum/6glq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6glq ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
-
Authors: Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A.
+
==See Also==
-
 
+
*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
-
Description: hMTH1 N33G in complex with LW14.
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Caflisch, A]]
+
__TOC__
-
[[Category: Wiedmer, L]]
+
</StructureSection>
-
[[Category: Sledz, P]]
+
[[Category: Homo sapiens]]
-
[[Category: Eberle, S.A]]
+
[[Category: Large Structures]]
 +
[[Category: Caflisch A]]
 +
[[Category: Eberle SA]]
 +
[[Category: Sledz P]]
 +
[[Category: Wiedmer L]]

Current revision

Crystal structure of hMTH1 N33G in complex with LW14 in the absence of acetate

PDB ID 6glq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6glq"
Personal tools