This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6gmb
From Proteopedia
(Difference between revisions)
m (Protected "6gmb" [edit=sysop:move=sysop]) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human hydroxyacid oxidase 1 bound with FMN and glycolate== | |
| + | <StructureSection load='6gmb' size='340' side='right'caption='[[6gmb]], [[Resolution|resolution]] 1.35Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6gmb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GMB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOA:GLYCOLIC+ACID'>GOA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6gmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gmb OCA], [https://pdbe.org/6gmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6gmb RCSB], [https://www.ebi.ac.uk/pdbsum/6gmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6gmb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. | ||
| - | + | ==See Also== | |
| - | + | *[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bezerra GA]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Brennan PE]] |
| - | [[Category: | + | [[Category: Edwards E]] |
| - | [[Category: | + | [[Category: Krojer T]] |
| - | [[Category: | + | [[Category: MacKinnon S]] |
| - | [[Category: | + | [[Category: Oppermann U]] |
| - | [[Category: | + | [[Category: Smee C]] |
| + | [[Category: Yue WW]] | ||
Current revision
Structure of human hydroxyacid oxidase 1 bound with FMN and glycolate
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bezerra GA | Bountra C | Brennan PE | Edwards E | Krojer T | MacKinnon S | Oppermann U | Smee C | Yue WW
