3hha

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==Crystal structure of cathepsin L in complex with AZ12878478==
==Crystal structure of cathepsin L in complex with AZ12878478==
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<StructureSection load='3hha' size='340' side='right' caption='[[3hha]], [[Resolution|resolution]] 1.27&Aring;' scene=''>
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<StructureSection load='3hha' size='340' side='right'caption='[[3hha]], [[Resolution|resolution]] 1.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hha]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HHA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hha]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HHA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOW:NALPHA-[(3-TERT-BUTYL-1-METHYL-1H-PYRAZOL-5-YL)CARBONYL]-N-[(2Z)-2-IMINOETHYL]-3-METHYL-L-PHENYLALANINAMIDE'>NOW</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.27&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSL1, CTSL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOW:NALPHA-[(3-TERT-BUTYL-1-METHYL-1H-PYRAZOL-5-YL)CARBONYL]-N-[(2Z)-2-IMINOETHYL]-3-METHYL-L-PHENYLALANINAMIDE'>NOW</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hha OCA], [https://pdbe.org/3hha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hha RCSB], [https://www.ebi.ac.uk/pdbsum/3hha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hha ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hha OCA], [http://pdbe.org/3hha PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hha RCSB], [http://www.ebi.ac.uk/pdbsum/3hha PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hha ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes.
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[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/3hha_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/3hha_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Cathepsin|Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cathepsin L]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Asaad, N]]
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[[Category: Asaad N]]
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[[Category: Augustin, M]]
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[[Category: Augustin M]]
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[[Category: Bethel, P A]]
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[[Category: Bethel PA]]
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[[Category: Coulson, M D]]
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[[Category: Coulson MD]]
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[[Category: Dawson, J]]
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[[Category: Dawson J]]
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[[Category: Ford, S J]]
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[[Category: Ford SJ]]
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[[Category: Gerhardt, S]]
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[[Category: Gerhardt S]]
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[[Category: Grist, M]]
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[[Category: Grist M]]
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[[Category: Hamlin, G A]]
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[[Category: Hamlin GA]]
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[[Category: James, M J]]
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[[Category: James MJ]]
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[[Category: Jones, E V]]
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[[Category: Jones EV]]
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[[Category: Karoutchi, G I]]
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[[Category: Karoutchi GI]]
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[[Category: Kenny, P W]]
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[[Category: Kenny PW]]
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[[Category: Krapp, S]]
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[[Category: Krapp S]]
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[[Category: Morley, A D]]
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[[Category: Morley AD]]
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[[Category: Oldham, K]]
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[[Category: Oldham K]]
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[[Category: Rankine, N]]
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[[Category: Rankine N]]
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[[Category: Ryan, D]]
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[[Category: Ryan D]]
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[[Category: Simader, H]]
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[[Category: Simader H]]
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[[Category: Steinbacher, S]]
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[[Category: Steinbacher S]]
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[[Category: Wells, S L]]
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[[Category: Wells SL]]
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[[Category: Wood, L]]
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[[Category: Wood L]]
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[[Category: Cathepsin l]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Lysosome]]
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[[Category: Protease]]
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[[Category: Proteros biostructures gmbh]]
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[[Category: Thiol protease]]
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[[Category: Zymogen]]
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Current revision

Crystal structure of cathepsin L in complex with AZ12878478

PDB ID 3hha

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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