2dm3

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==Solution structure of the second ig domain of human palladin==
==Solution structure of the second ig domain of human palladin==
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<StructureSection load='2dm3' size='340' side='right' caption='[[2dm3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2dm3' size='340' side='right'caption='[[2dm3]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2dm3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DM3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DM3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2dm3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DM3 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA0992 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dm3 OCA], [http://pdbe.org/2dm3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dm3 RCSB], [http://www.ebi.ac.uk/pdbsum/2dm3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dm3 ProSAT], [http://www.topsan.org/Proteins/RSGI/2dm3 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dm3 OCA], [https://pdbe.org/2dm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dm3 RCSB], [https://www.ebi.ac.uk/pdbsum/2dm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dm3 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dm3 TOPSAN]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PALLD_HUMAN PALLD_HUMAN] Familial pancreatic carcinoma. Disease susceptibility is associated with variants affecting the gene represented in this entry. Genetic variations in PALLD may be associated with susceptibility to myocardial infarction.<ref>PMID:16175505</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PALLD_HUMAN PALLD_HUMAN] Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci.<ref>PMID:11598191</ref> <ref>PMID:15147863</ref> <ref>PMID:17537434</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dm3 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dm3 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Hayashi, F]]
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[[Category: Large Structures]]
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[[Category: Nagashima, T]]
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[[Category: Hayashi F]]
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[[Category: Structural genomic]]
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[[Category: Nagashima T]]
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[[Category: Yokoyama, S]]
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[[Category: Yokoyama S]]
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[[Category: Actin-associated scaffold]]
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[[Category: Beta-sandwich]]
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[[Category: Kiaa0992]]
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[[Category: Myopalladin]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Protein binding]]
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[[Category: Rsgi]]
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Current revision

Solution structure of the second ig domain of human palladin

PDB ID 2dm3

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