We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
Sandbox 7712
From Proteopedia
(Difference between revisions)
m |
|||
| (16 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
==Your Heading Here (maybe something like 'Structure')== | ==Your Heading Here (maybe something like 'Structure')== | ||
| - | <StructureSection load=' | + | <StructureSection load='1acj_au' size='340' side='right' caption='Caption for this structure' scene=''> |
| - | + | <scene name='78/789340/Tacrine_in_active_site/4'>Tacrine in active site</scene><ref>PMID:21638687</ref> to the rescue. | |
| - | + | ||
| + | |||
| + | 1ACJ* shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine | ||
| + | |||
| + | Tacrine was the first cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | ||
| + | |||
| + | Tacrine’s ringed structure is stacked between the aromatic rings of Trp84 and Phe330<ref>PMID:8415649</ref> | ||
| + | |||
| + | [http://pross.weizmann.ac.il http://pross.weizmann.ac.il ] | ||
| + | |||
| + | |||
| + | <scene name='78/789340/Label_-_2/2'>Label-2</scene> | ||
== Function == | == Function == | ||
Current revision
Your Heading Here (maybe something like 'Structure')
| |||||||||||
References
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
