5zhy

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==Structural characterization of the HCoV-229E fusion core==
==Structural characterization of the HCoV-229E fusion core==
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<StructureSection load='5zhy' size='340' side='right' caption='[[5zhy]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
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<StructureSection load='5zhy' size='340' side='right'caption='[[5zhy]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zhy]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZHY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zhy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_229E Human coronavirus 229E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZHY FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zhy OCA], [http://pdbe.org/5zhy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zhy RCSB], [http://www.ebi.ac.uk/pdbsum/5zhy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zhy ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.441&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zhy OCA], [https://pdbe.org/5zhy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zhy RCSB], [https://www.ebi.ac.uk/pdbsum/5zhy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zhy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SPIKE_CVH22 SPIKE_CVH22]] S1 region attaches the virion to the cell membrane by interacting with human ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).
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[https://www.uniprot.org/uniprot/SPIKE_CVH22 SPIKE_CVH22] S1 region attaches the virion to the cell membrane by interacting with human ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5zhy" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5zhy" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Sandbox 3001|Sandbox 3001]]
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*[[Spike protein|Spike protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chen, X]]
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[[Category: Human coronavirus 229E]]
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[[Category: Rao, Z]]
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[[Category: Large Structures]]
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[[Category: Yan, M]]
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[[Category: Chen X]]
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[[Category: Yang, H]]
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[[Category: Rao Z]]
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[[Category: Zhang, W]]
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[[Category: Yan M]]
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[[Category: Zheng, Q]]
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[[Category: Yang H]]
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[[Category: Zhou, W]]
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[[Category: Zhang W]]
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[[Category: Broad-spectrum inhibitor design]]
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[[Category: Zheng Q]]
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[[Category: Membrane fusion]]
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[[Category: Zhou W]]
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[[Category: Viral protein]]
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Current revision

Structural characterization of the HCoV-229E fusion core

PDB ID 5zhy

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