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2e4u
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==Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with L-glutamate== | ==Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with L-glutamate== | ||
| - | <StructureSection load='2e4u' size='340' side='right' caption='[[2e4u]], [[Resolution|resolution]] 2.35Å' scene=''> | + | <StructureSection load='2e4u' size='340' side='right'caption='[[2e4u]], [[Resolution|resolution]] 2.35Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2e4u]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2e4u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E4U FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e4u OCA], [https://pdbe.org/2e4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e4u RCSB], [https://www.ebi.ac.uk/pdbsum/2e4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e4u ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/GRM3_RAT GRM3_RAT] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Metabotropic glutamate receptor|Metabotropic glutamate receptor]] | + | *[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Jingami | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Morikawa | + | [[Category: Jingami H]] |
| - | [[Category: Muto | + | [[Category: Morikawa K]] |
| - | [[Category: Tsuchiya | + | [[Category: Muto T]] |
| - | + | [[Category: Tsuchiya D]] | |
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Current revision
Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with L-glutamate
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