2ed1

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==Solution structure of the SH3 domain of 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein==
==Solution structure of the SH3 domain of 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein==
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<StructureSection load='2ed1' size='340' side='right' caption='[[2ed1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2ed1' size='340' side='right'caption='[[2ed1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ed1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ED1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ed1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ED1 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDEF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ed1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ed1 OCA], [http://pdbe.org/2ed1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ed1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ed1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ed1 ProSAT], [http://www.topsan.org/Proteins/RSGI/2ed1 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ed1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ed1 OCA], [https://pdbe.org/2ed1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ed1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ed1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ed1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ed1 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ASAP1_HUMAN ASAP1_HUMAN]] Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.<ref>PMID:20393563</ref>
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[https://www.uniprot.org/uniprot/ASAP1_HUMAN ASAP1_HUMAN] Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.<ref>PMID:20393563</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Abe, H]]
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[[Category: Large Structures]]
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[[Category: Kigawa, T]]
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[[Category: Abe H]]
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[[Category: Miyamoto, K]]
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[[Category: Kigawa T]]
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[[Category: Structural genomic]]
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[[Category: Miyamoto K]]
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[[Category: Saito, K]]
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[[Category: Saito K]]
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[[Category: Tochio, N]]
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[[Category: Tochio N]]
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[[Category: Yokoyama, S]]
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[[Category: Yokoyama S]]
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[[Category: Gtpase activation]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Sh3 domain]]
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[[Category: Signaling protein]]
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[[Category: Zinc-finger]]
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Current revision

Solution structure of the SH3 domain of 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein

PDB ID 2ed1

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