2edz

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==Solution structures of the PDZ domain of mus musculus PDZ domain-containing protein 1==
==Solution structures of the PDZ domain of mus musculus PDZ domain-containing protein 1==
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<StructureSection load='2edz' size='340' side='right' caption='[[2edz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2edz' size='340' side='right'caption='[[2edz]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2edz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EDZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2edz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EDZ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pdzk1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2edz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edz OCA], [http://pdbe.org/2edz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2edz RCSB], [http://www.ebi.ac.uk/pdbsum/2edz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2edz ProSAT], [http://www.topsan.org/Proteins/RSGI/2edz TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2edz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edz OCA], [https://pdbe.org/2edz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2edz RCSB], [https://www.ebi.ac.uk/pdbsum/2edz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2edz ProSAT], [https://www.topsan.org/Proteins/RSGI/2edz TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NHRF3_MOUSE NHRF3_MOUSE]] A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism (By similarity). May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.<ref>PMID:11051556</ref> <ref>PMID:12556478</ref> <ref>PMID:14531806</ref> <ref>PMID:15523054</ref>
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[https://www.uniprot.org/uniprot/NHRF3_MOUSE NHRF3_MOUSE] A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism (By similarity). May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.<ref>PMID:11051556</ref> <ref>PMID:12556478</ref> <ref>PMID:14531806</ref> <ref>PMID:15523054</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2edz ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2edz ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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==See Also==
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*[[Sodium-hydrogen exchange regulatory factor 3D structures|Sodium-hydrogen exchange regulatory factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Harada, T]]
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[[Category: Mus musculus]]
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[[Category: Kigawa, T]]
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[[Category: Harada T]]
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[[Category: Koshiba, S]]
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[[Category: Kigawa T]]
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[[Category: Structural genomic]]
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[[Category: Koshiba S]]
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[[Category: Sato, M]]
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[[Category: Sato M]]
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[[Category: Watanabe, S]]
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[[Category: Watanabe S]]
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[[Category: Yokoyama, S]]
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[[Category: Yokoyama S]]
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[[Category: Cftr-associated protein of 70 kda]]
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[[Category: Na/pi cotransporter c-terminal-associated protein]]
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[[Category: Napi-cap1]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Signaling protein]]
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[[Category: Sodium-hydrogen exchanger regulatory factor 3]]
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Current revision

Solution structures of the PDZ domain of mus musculus PDZ domain-containing protein 1

PDB ID 2edz

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