2ec1
From Proteopedia
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==Solution structure of the RanBD1 domain from human Nucleoporin 50 kDa== | ==Solution structure of the RanBD1 domain from human Nucleoporin 50 kDa== | ||
| - | <StructureSection load='2ec1' size='340' side='right' caption='[[2ec1 | + | <StructureSection load='2ec1' size='340' side='right'caption='[[2ec1]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ec1]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ec1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EC1 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ec1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec1 OCA], [https://pdbe.org/2ec1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ec1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ec1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ec1 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NUP50_HUMAN NUP50_HUMAN] Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.<ref>PMID:20016008</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Nucleoporin|Nucleoporin]] | + | *[[Nucleoporin 3D structures|Nucleoporin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Hayashi F]] |
| - | [[Category: | + | [[Category: Kurosaki C]] |
| - | [[Category: Yokoyama | + | [[Category: Yokoyama S]] |
| - | [[Category: Yoshida | + | [[Category: Yoshida M]] |
| - | [[Category: Zhang | + | [[Category: Zhang HP]] |
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Current revision
Solution structure of the RanBD1 domain from human Nucleoporin 50 kDa
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