2dvr

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==Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide==
==Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide==
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<StructureSection load='2dvr' size='340' side='right' caption='[[2dvr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='2dvr' size='340' side='right'caption='[[2dvr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2dvr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DVR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2dvr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DVR FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1x0j|1x0j]], [[2dvq|2dvq]], [[2dvs|2dvs]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dvr OCA], [http://pdbe.org/2dvr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dvr RCSB], [http://www.ebi.ac.uk/pdbsum/2dvr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dvr ProSAT], [http://www.topsan.org/Proteins/RSGI/2dvr TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dvr OCA], [https://pdbe.org/2dvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dvr RCSB], [https://www.ebi.ac.uk/pdbsum/2dvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dvr ProSAT], [https://www.topsan.org/Proteins/RSGI/2dvr TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/2dvr_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/2dvr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[Bromodomain-containing protein|Bromodomain-containing protein]]
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Nakamura, Y]]
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[[Category: Large Structures]]
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[[Category: Padmanabhan, B]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Structural genomic]]
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[[Category: Nakamura Y]]
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[[Category: Shirouzu, M]]
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[[Category: Padmanabhan B]]
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[[Category: Umehara, T]]
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[[Category: Shirouzu M]]
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[[Category: Yokoyama, S]]
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[[Category: Umehara T]]
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[[Category: Alpha-helical domain]]
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[[Category: Yokoyama S]]
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[[Category: Binds to acetylated histone]]
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[[Category: Bromodomain]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Transcription]]
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Current revision

Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide

PDB ID 2dvr

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