Gp41

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<StructureSection load='1aik' size='340' side='right' caption='Core structure of acetylated gp41 from the HIV envelope glycoprotein, [[1aik]].' scene=''>
<StructureSection load='1aik' size='340' side='right' caption='Core structure of acetylated gp41 from the HIV envelope glycoprotein, [[1aik]].' scene=''>
== Function ==
== Function ==
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'''Gp41''' is a subunit of the envelope protein of retrovirus<ref>PMID:9630213</ref>. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see [[Hiv env proteins]].
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'''Gp41''' is a subunit of the envelope protein of retrovirus<ref>PMID:9630213</ref>. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see [[Hiv env proteins|HIV-1 viral envelope proteins]].
== Relevance ==
== Relevance ==
Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell<ref>PMID:15180542</ref>.
Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell<ref>PMID:15180542</ref>.
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</StructureSection>
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== 3D Structures of Gp41 ==
== 3D Structures of Gp41 ==
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[[Gp41 3D Structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Gp41 from HIV-1
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**[[1aik]], [[1df4]], [[1df5]], [[1qr8]], [[1qr9]], [[1dlb]], [[1jpx]] – Gp41 thermostable core domain residues 544-579, 623-656<br />
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**[[1env]], [[3cp1]], [[3cyo]], [[1f23]], [[1k33]], [[1k34]], [[1i5x]], [[1i5y]], [[2ot5]], [[5ka6]], [[5ka5]] – Gp41 thermostable core domain (mutant)<br />
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**[[3k9a]] – Gp41 residues 1-108 (mutant)<br />
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**[[1szt]] – Gp41 thermostable domain residues 541-574<br />
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**[[6b3u]] – Gp41 transmembrane domain residues 670-709 - NMR<br />
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**[[5vwl]] – Gp41 tail residues 750-854 - NMR<br />
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**[[2z2t]], [[2zzo]], [[3aha]], [[3vie]], [[2r3c]], [[2r5b]], [[2r5d]], [[3l36]], [[3l37]], [[3vgy]], [[3vh7]], [[3vtp]], [[3vu5]], [[3vu6]], [[5h0n]] – Gp41 N-heptad repeat + Gp41 fusion inhibitor peptide<br />
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**[[2zfc]] – Gp41 N-terminal residues 1-49 <br />
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**[[3u91]] – Gp41 N-terminal residues 7-39<br />
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**[[4hlr]] – Gp41 N-terminal (mutant) <br />
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**[[4i2l]] – Gp41 N-peptide residues 549-589 (mutant)<br />
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**[[5v8l]], [[5v8m]], [[5uty]], [[5utf]], [[5um8]], [[5jsa]], [[5js9]], [[5i8h]], [[5d9q]], [[5cjx]], [[5c7k]], [[6ck9]], [[6chb]], [[6ch9]], [[6ch8]], [[6ch7]], [[5w6d]], [[4nrx]] – Gp41 + Gp120 + antibody<br />
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**[[6cdi]] – Gp41 + Gp120 + antibody – Cryo EM<br />
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**[[5u1f]], [[5thr]] – Gp41 + Gp120 + antibody + CD4<br />
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**[[5fyk]], [[5fyj]], [[4nco]] – Gp41 + Gp120 (mutant) + antibody<br />
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**[[5hm1]] – Gp41 + llama antibody <br />
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**[[3o3x]] – arGp41 - artificial<br />
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**[[4dzu]] – arGp41 + 3-α<br />
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**[[4dzv]] – arGp41 + 4-α/β<br />
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*Gp41 from Simian Immunodeficiency Virus
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**[[2siv]] – Gp41 core<br />
 
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**[[2ezo]], [[2ezp]], [[2ezq]], [[2ezr]], [[2ezs]], [[1qce]] – Gp41 core - NMR<br />
 
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**[[1qbz]], [[1jq0]] – Gp41 core (mutant)<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Core structure of acetylated gp41 from the HIV envelope glycoprotein, 1aik.

Drag the structure with the mouse to rotate

References

  1. ↑ Chan DC, Kim PS. HIV entry and its inhibition. Cell. 1998 May 29;93(5):681-4. PMID:9630213
  2. ↑ Root MJ, Steger HK. HIV-1 gp41 as a target for viral entry inhibition. Curr Pharm Des. 2004;10(15):1805-25. PMID:15180542

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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