2j66
From Proteopedia
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| - | [[Image:2j66.jpg|left|200px]] | ||
| - | + | ==Structural characterisation of BtrK decarboxylase from butirosin biosynthesis== | |
| - | + | <StructureSection load='2j66' size='340' side='right'caption='[[2j66]], [[Resolution|resolution]] 1.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2j66]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Niallia_circulans Niallia circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J66 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j66 OCA], [https://pdbe.org/2j66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j66 RCSB], [https://www.ebi.ac.uk/pdbsum/2j66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j66 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/BTRK_NIACI BTRK_NIACI] Pyridoxal phosphate-dependent decarboxylase that catalyzes 1 step in the biosynthesis of the side chain of the aminoglycoside antibiotics in the biosynthetic pathway of butirosin. Able to decarboxylate L-ornithine, L-arginine, L-lysine, but not L-glutamate or any D-amino acids. Has low activity with substrates not bound to an acyl-carrier protein.<ref>PMID:15975512</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | == | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j6/2j66_consurf.spt"</scriptWhenChecked> |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | [[Category: | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[Category: | + | </jmolCheckbox> |
| - | [[Category: Blundell | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j66 ConSurf]. |
| - | [[Category: Chirgadze | + | <div style="clear:both"></div> |
| - | [[Category: Li | + | == References == |
| - | [[Category: Popovic | + | <references/> |
| - | [[Category: Spencer | + | __TOC__ |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Niallia circulans]] | |
| - | + | [[Category: Blundell TL]] | |
| - | + | [[Category: Chirgadze DY]] | |
| - | + | [[Category: Li Y]] | |
| + | [[Category: Popovic B]] | ||
| + | [[Category: Spencer JB]] | ||
Current revision
Structural characterisation of BtrK decarboxylase from butirosin biosynthesis
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