6dm8
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6dm8 is ON HOLD Authors: Zhao, B. Description: Understanding the Species Selectivity of Myeloid cell leukemia-1 (Mcl-1) inhibitors [[Category: Unre...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Understanding the Species Selectivity of Myeloid cell leukemia-1 (Mcl-1) inhibitors== | |
| + | <StructureSection load='6dm8' size='340' side='right'caption='[[6dm8]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6dm8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DM8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6AK:4-{8-CHLORO-11-[3-(4-CHLORO-3,5-DIMETHYLPHENOXY)PROPYL]-1-OXO-7-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)-4,5-DIHYDRO-1H-[1,4]DIAZEPINO[1,2-A]INDOL-2(3H)-YL}-1-METHYL-1H-INDOLE-6-CARBOXYLIC+ACID'>6AK</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dm8 OCA], [https://pdbe.org/6dm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dm8 RCSB], [https://www.ebi.ac.uk/pdbsum/6dm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dm8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. | ||
| - | + | ==See Also== | |
| - | + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |
| - | + | *[[Maltose-binding protein 3D structures|Maltose-binding protein 3D structures]] | |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Zhao | + | </StructureSection> |
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Zhao B]] | ||
Current revision
Understanding the Species Selectivity of Myeloid cell leukemia-1 (Mcl-1) inhibitors
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