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6glo
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of hMTH1 N33G in the presence of acetate== | |
| - | + | <StructureSection load='6glo' size='340' side='right' caption='[[6glo]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6glo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GLO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6glo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6glo OCA], [http://pdbe.org/6glo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6glo RCSB], [http://www.ebi.ac.uk/pdbsum/6glo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6glo ProSAT]</span></td></tr> |
| - | + | </table> | |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Caflisch, A]] | [[Category: Caflisch, A]] | ||
| + | [[Category: Eberle, S A]] | ||
[[Category: Sledz, P]] | [[Category: Sledz, P]] | ||
[[Category: Wiedmer, L]] | [[Category: Wiedmer, L]] | ||
| + | [[Category: Dna repair]] | ||
| + | [[Category: Hydrolase]] | ||
Current revision
Crystal structure of hMTH1 N33G in the presence of acetate
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