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6dk4

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==Crystal structure of Campylobacter jejuni peroxide stress regulator==
==Crystal structure of Campylobacter jejuni peroxide stress regulator==
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<StructureSection load='6dk4' size='340' side='right' caption='[[6dk4]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
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<StructureSection load='6dk4' size='340' side='right'caption='[[6dk4]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6dk4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DK4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6dk4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DK4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dk4 OCA], [http://pdbe.org/6dk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dk4 RCSB], [http://www.ebi.ac.uk/pdbsum/6dk4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dk4 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dk4 OCA], [https://pdbe.org/6dk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dk4 RCSB], [https://www.ebi.ac.uk/pdbsum/6dk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dk4 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q0PBI7_CAMJE Q0PBI7_CAMJE]
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In Campylobacter jejuni (Cj), the metal-cofactored peroxide response regulator (PerR) transcription factor allows C. jejuni to respond to oxidative stresses. The crystal structure of the metalated form of CjPerR shows that the protein folds as an asymmetric dimer displaying structural differences in the orientation of its DNA-binding domain. Comparative analysis shows that such asymmetry is a conserved feature among crystallized PerR proteins, and mutational analysis reveals that residues found in the first alpha-helix of CjPerR contribute to DNA binding. These studies present the structure of CjPerR protein and highlight structural heterogeneity in the orientation of the metalated PerR DNA-binding domain which may underlie the ability of PerR to recognize DNA, control gene expression and contribute to bacterial pathogenesis. This article is protected by copyright. All rights reserved.
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Crystal structure of Campylobacter jejuni Peroxide Regulator.,Sarvan S, Charih F, Butcher J, Brunzelle JS, Stintzi A, Couture JF FEBS Lett. 2018 Jun 1. doi: 10.1002/1873-3468.13120. PMID:29856899<ref>PMID:29856899</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6dk4" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brunzelle, J S]]
 
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[[Category: Couture, J F]]
 
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[[Category: Sarvan, S]]
 
[[Category: Campylobacter jejuni]]
[[Category: Campylobacter jejuni]]
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[[Category: Ferric uptake regulator]]
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[[Category: Large Structures]]
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[[Category: Metal transport]]
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[[Category: Brunzelle JS]]
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[[Category: Peroxide stress]]
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[[Category: Couture JF]]
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[[Category: Perr]]
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[[Category: Sarvan S]]

Current revision

Crystal structure of Campylobacter jejuni peroxide stress regulator

PDB ID 6dk4

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