5nw7

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==Crystal structure of candida albicans phosphomannose isomerase in complex with inhibitor==
==Crystal structure of candida albicans phosphomannose isomerase in complex with inhibitor==
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<StructureSection load='5nw7' size='340' side='right' caption='[[5nw7]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='5nw7' size='340' side='right'caption='[[5nw7]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nw7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NW7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nw7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NW7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9C2:[(2~{R},3~{R},4~{S})-5-diazanyl-2,3,4-tris(oxidanyl)-5-oxidanylidene-pentyl]+dihydrogen+phosphate'>9C2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PMI1, MANA, CAALFM_C209640WA, CaO19.1390 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 ATCC 11006 [[Candida stellatoidea]]])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9C2:[(2~{R},3~{R},4~{S})-5-diazanyl-2,3,4-tris(oxidanyl)-5-oxidanylidene-pentyl]+dihydrogen+phosphate'>9C2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannose-6-phosphate_isomerase Mannose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.8 5.3.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nw7 OCA], [https://pdbe.org/5nw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nw7 RCSB], [https://www.ebi.ac.uk/pdbsum/5nw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nw7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nw7 OCA], [http://pdbe.org/5nw7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nw7 RCSB], [http://www.ebi.ac.uk/pdbsum/5nw7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nw7 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MPI_CANAL MPI_CANAL]] Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
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[https://www.uniprot.org/uniprot/MPI_CANAL MPI_CANAL] Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mannose-6-phosphate isomerase]]
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[[Category: Candida albicans]]
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[[Category: Ahmad, L]]
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[[Category: Large Structures]]
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[[Category: Plancqueel, S]]
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[[Category: Ahmad L]]
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[[Category: Salmon, L]]
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[[Category: Li de la Sierra-Gallay I]]
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[[Category: Sierra-Gallay, I Li de la]]
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[[Category: Plancqueel S]]
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[[Category: Tilbeurgh, H van]]
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[[Category: Salmon L]]
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[[Category: Aldose-ketose isomerase]]
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[[Category: Van Tilbeurgh H]]
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[[Category: Complex inhibitor]]
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[[Category: Isomerase]]
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Current revision

Crystal structure of candida albicans phosphomannose isomerase in complex with inhibitor

PDB ID 5nw7

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