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2jb8

From Proteopedia

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[[Image:2jb8.jpg|left|200px]]
 
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{{Structure
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==Deacetoxycephalosporin C synthase complexed with 5-hydroxy-4-keto valeric acid==
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|PDB= 2jb8 |SIZE=350|CAPTION= <scene name='initialview01'>2jb8</scene>, resolution 1.53&Aring;
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<StructureSection load='2jb8' size='340' side='right'caption='[[2jb8]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Fe+Binding+Site+For+Residue+A+1309'>AC1</scene> and <scene name='pdbsite=AC2:Hkv+Binding+Site+For+Residue+A+1310'>AC2</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HKV:4,5-DIOXOPENTANOIC+ACID'>HKV</scene>
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<table><tr><td colspan='2'>[[2jb8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_clavuligerus Streptomyces clavuligerus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JB8 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Deacetoxycephalosporin-C_synthase Deacetoxycephalosporin-C synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.20.1 1.14.20.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HKV:4,5-DIOXOPENTANOIC+ACID'>HKV</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jb8 OCA], [https://pdbe.org/2jb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jb8 RCSB], [https://www.ebi.ac.uk/pdbsum/2jb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jb8 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1dcs|1DCS]], [[1e5h|1E5H]], [[1e5i|1E5I]], [[1hjf|1HJF]], [[1hjg|1HJG]], [[1rxf|1RXF]], [[1rxg|1RXG]], [[1unb|1UNB]], [[1uo9|1UO9]], [[1uob|1UOB]], [[1uof|1UOF]], [[1uog|1UOG]], [[1w28|1W28]], [[1w2a|1W2A]], [[1w2n|1W2N]], [[1w2o|1W2O]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jb8 OCA], [http://www.ebi.ac.uk/pdbsum/2jb8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jb8 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CEFE_STRCL CEFE_STRCL] Catalyzes the step from penicillin N to deacetoxy-cephalosporin C.
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== Evolutionary Conservation ==
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'''DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH 5-HYDROXY-4-KETO VALERIC ACID'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/2jb8_consurf.spt"</scriptWhenChecked>
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2JB8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_clavuligerus Streptomyces clavuligerus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JB8 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Deacetoxycephalosporin-C synthase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Single protein]]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jb8 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces clavuligerus]]
[[Category: Streptomyces clavuligerus]]
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[[Category: Andersson, I.]]
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[[Category: Andersson I]]
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[[Category: Carbonera, C.]]
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[[Category: Carbonera C]]
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[[Category: Cicero, G.]]
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[[Category: Cicero G]]
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[[Category: Hajdu, J.]]
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[[Category: Hajdu J]]
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[[Category: Ranghino, G.]]
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[[Category: Ranghino G]]
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[[Category: Valegard, K.]]
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[[Category: Valegard K]]
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[[Category: antibiotic biosynthesis]]
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[[Category: deacetoxycephalosporin c synthase]]
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[[Category: iron]]
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[[Category: mononuclear ferrous enzyme]]
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[[Category: oxidoreductase]]
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[[Category: vitamin c]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:55:42 2008''
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Current revision

Deacetoxycephalosporin C synthase complexed with 5-hydroxy-4-keto valeric acid

PDB ID 2jb8

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