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2f13

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==Crystal Structure of the Human Sialidase Neu2 in Complex with 2',3'- dihydroxypropyl ether mimetic Inhibitor==
==Crystal Structure of the Human Sialidase Neu2 in Complex with 2',3'- dihydroxypropyl ether mimetic Inhibitor==
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<StructureSection load='2f13' size='340' side='right' caption='[[2f13]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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<StructureSection load='2f13' size='340' side='right'caption='[[2f13]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2f13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F13 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2f13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F13 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DYM:6-(2,3-DIHYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>DYM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1snt|1snt]], [[1so7|1so7]], [[1vcu|1vcu]], [[2f0z|2f0z]], [[2f10|2f10]], [[2f11|2f11]], [[2f12|2f12]], [[2f24|2f24]], [[2f25|2f25]], [[2f26|2f26]], [[2f27|2f27]], [[2f28|2f28]], [[2f29|2f29]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DYM:6-(2,3-DIHYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>DYM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f13 OCA], [https://pdbe.org/2f13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f13 RCSB], [https://www.ebi.ac.uk/pdbsum/2f13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f13 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f13 OCA], [http://pdbe.org/2f13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f13 RCSB], [http://www.ebi.ac.uk/pdbsum/2f13 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f13 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN]] Hydrolyzes sialylated compounds.
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[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Neuraminidase|Neuraminidase]]
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Exo-alpha-sialidase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Chavas, L M.G]]
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[[Category: Chavas LMG]]
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[[Category: Dyason, J C]]
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[[Category: Dyason JC]]
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[[Category: Fusi, P]]
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[[Category: Fusi P]]
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[[Category: Itzstein, M von]]
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[[Category: Kato R]]
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[[Category: Kato, R]]
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[[Category: Mann MC]]
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[[Category: Mann, M C]]
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[[Category: Monti E]]
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[[Category: Monti, E]]
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[[Category: Tettamanti G]]
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[[Category: Tettamanti, G]]
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[[Category: Thomson RJ]]
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[[Category: Thomson, R J]]
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[[Category: Tringali C]]
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[[Category: Tringali, C]]
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[[Category: Venerando B]]
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[[Category: Venerando, B]]
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[[Category: Wakatsuki S]]
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[[Category: Wakatsuki, S]]
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[[Category: Von Itzstein M]]
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[[Category: Drug design]]
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[[Category: Hydrolase]]
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[[Category: Influenza virus]]
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[[Category: Neuraminidase]]
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[[Category: Sialidase]]
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Current revision

Crystal Structure of the Human Sialidase Neu2 in Complex with 2',3'- dihydroxypropyl ether mimetic Inhibitor

PDB ID 2f13

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