6a2s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Mycobacterium tuberculosis LexA C-domain S160A== | |
| - | + | <StructureSection load='6a2s' size='340' side='right'caption='[[6a2s]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6a2s]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A2S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| - | [[Category: Chandran | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a2s OCA], [https://pdbe.org/6a2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a2s RCSB], [https://www.ebi.ac.uk/pdbsum/6a2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a2s ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Srikalaivani | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/LEXA_MYCTU LEXA_MYCTU] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Has been shown to bind to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Chandran AV]] | ||
| + | [[Category: Paul A]] | ||
| + | [[Category: Srikalaivani R]] | ||
| + | [[Category: Vijayan M]] | ||
Current revision
Mycobacterium tuberculosis LexA C-domain S160A
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