2jfk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:46, 13 December 2023) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2jfk.gif|left|200px]]
 
-
{{Structure
+
==Structure of the MAT domain of human FAS with malonyl-CoA==
-
|PDB= 2jfk |SIZE=350|CAPTION= <scene name='initialview01'>2jfk</scene>, resolution 2.40&Aring;
+
<StructureSection load='2jfk' size='340' side='right'caption='[[2jfk]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
|SITE= <scene name='pdbsite=AC1:Coa+Binding+Site+For+Chain+D'>AC1</scene>
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MCS:MALONYL+CYSTEINE'>MCS</scene>
+
<table><tr><td colspan='2'>[[2jfk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JFK FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty-acid_synthase Fatty-acid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.85 2.3.1.85] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MCS:MALONYL+CYSTEINE'>MCS</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfk OCA], [https://pdbe.org/2jfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jfk RCSB], [https://www.ebi.ac.uk/pdbsum/2jfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jfk ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfk OCA], [http://www.ebi.ac.uk/pdbsum/2jfk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jfk RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/FAS_HUMAN FAS_HUMAN] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/2jfk_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jfk ConSurf].
 +
<div style="clear:both"></div>
-
'''STRUCTURE OF THE MAT DOMAIN OF HUMAN FAS WITH MALONYL-COA'''
+
==See Also==
-
 
+
*[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
2JFK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFK OCA].
+
-
[[Category: Fatty-acid synthase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bunkoczi, G.]]
+
[[Category: Bunkoczi G]]
-
[[Category: Edwards, A.]]
+
[[Category: Edwards A]]
-
[[Category: Hozjan, V.]]
+
[[Category: Hozjan V]]
-
[[Category: Kavanagh, K.]]
+
[[Category: Kavanagh K]]
-
[[Category: Oppermann, U.]]
+
[[Category: Oppermann U]]
-
[[Category: Rojkova, A.]]
+
[[Category: Rojkova A]]
-
[[Category: Smith, S.]]
+
[[Category: Smith S]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Sundstrom M]]
-
[[Category: Watt, S.]]
+
[[Category: Watt S]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt J]]
-
[[Category: Wu, X.]]
+
[[Category: Wu X]]
-
[[Category: acetyl transferase]]
+
-
[[Category: acetylation]]
+
-
[[Category: fatty acid biosynthesis]]
+
-
[[Category: fatty acid synthase]]
+
-
[[Category: hydrolase]]
+
-
[[Category: lipid synthesis]]
+
-
[[Category: lyase]]
+
-
[[Category: malonyl transferase]]
+
-
[[Category: malonylation]]
+
-
[[Category: mat domain]]
+
-
[[Category: multifunctional enzyme]]
+
-
[[Category: nad]]
+
-
[[Category: nadp]]
+
-
[[Category: oxidoreductase]]
+
-
[[Category: phosphopantetheine]]
+
-
[[Category: phosphorylation]]
+
-
[[Category: pyridoxal phosphate]]
+
-
[[Category: transferase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:57:27 2008''
+

Current revision

Structure of the MAT domain of human FAS with malonyl-CoA

PDB ID 2jfk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jfk"
Personal tools