6ds5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6ds5" [edit=sysop:move=sysop])
Current revision (05:41, 28 May 2025) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6ds5 is ON HOLD
+
==Cryo EM structure of human SEIPIN==
 +
<SX load='6ds5' size='340' side='right' viewer='molstar' caption='[[6ds5]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[6ds5]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DS5 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ds5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ds5 OCA], [https://pdbe.org/6ds5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ds5 RCSB], [https://www.ebi.ac.uk/pdbsum/6ds5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ds5 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/BSCL2_HUMAN BSCL2_HUMAN] Autosomal dominant spastic paraplegia type 17;Severe neurodegenerative syndrome with lipodystrophy;Distal hereditary motor neuropathy type 5;Berardinelli-Seip congenital lipodystrophy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BSCL2_HUMAN BSCL2_HUMAN] Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues.<ref>PMID:19278620</ref> <ref>PMID:21533227</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The biogenesis of lipid droplets (LDs) and the development of adipocytes are two key aspects of mammalian fat storage. SEIPIN, an integral membrane protein of the endoplasmic reticulum (ER), plays a critical role in both LD formation and adipogenesis. The molecular function of SEIPIN, however, has yet to be elucidated. Here, we report the cryogenic electron microscopy structure of human SEIPIN at 3.8 A resolution. SEIPIN exists as an undecamer, and this oligomerization state is critical for its physiological function. The evolutionarily conserved lumenal domain of SEIPIN forms an eight-stranded beta sandwich fold. Both full-length SEIPIN and its lumenal domain can bind anionic phospholipids including phosphatidic acid. Our results suggest that SEIPIN forms a scaffold that helps maintain phospholipid homeostasis and surface tension of the ER.
-
Authors:
+
Human SEIPIN Binds Anionic Phospholipids.,Yan R, Qian H, Lukmantara I, Gao M, Du X, Yan N, Yang H Dev Cell. 2018 Oct 22;47(2):248-256.e4. doi: 10.1016/j.devcel.2018.09.010. Epub, 2018 Oct 4. PMID:30293840<ref>PMID:30293840</ref>
-
Description:
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
 +
<div class="pdbe-citations 6ds5" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</SX>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Qian HW]]
 +
[[Category: Yan N]]
 +
[[Category: Yan RH]]
 +
[[Category: Yang HY]]

Current revision

Cryo EM structure of human SEIPIN

6ds5, resolution 3.80Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6ds5"
Personal tools