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5ybh

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==Structural of the highly conserved ATPase from type III secretion system of bacterial pathogens==
==Structural of the highly conserved ATPase from type III secretion system of bacterial pathogens==
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<StructureSection load='5ybh' size='340' side='right' caption='[[5ybh]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='5ybh' size='340' side='right'caption='[[5ybh]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ybh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YBH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YBH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ybh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YBH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2obl|2obl]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ybh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ybh OCA], [https://pdbe.org/5ybh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ybh RCSB], [https://www.ebi.ac.uk/pdbsum/5ybh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ybh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ybh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ybh OCA], [http://pdbe.org/5ybh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ybh RCSB], [http://www.ebi.ac.uk/pdbsum/5ybh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ybh ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SPAL_SHIFL SPAL_SHIFL]] Required for surface presentation of invasion plasmid antigens. Probable catalytic subunit of a protein translocase. Required for invasion and for secretion of the three IPA proteins.
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[https://www.uniprot.org/uniprot/SCTN_SHIFL SCTN_SHIFL] ATPase component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:26947936, PubMed:27770024, PubMed:29595954). Acts as a molecular motor to provide the energy that is required for the export of proteins (Probable). Required for type III secretion apparatus (T3SA) formation, proper protein secretion, host cell invasion and virulence (PubMed:26947936, PubMed:27770024, PubMed:31162724). May play a critical role in T3SS substrate recognition, disassembly of the effector/chaperone complex and unfolding of the effector in an ATP-dependent manner prior to secretion (By similarity).[UniProtKB:P0A1B9]<ref>PMID:26947936</ref> <ref>PMID:27770024</ref> <ref>PMID:29595954</ref> <ref>PMID:31162724</ref> <ref>PMID:26947936</ref> <ref>PMID:27770024</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cui, S]]
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[[Category: Large Structures]]
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[[Category: Gao, X P]]
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[[Category: Shigella flexneri]]
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[[Category: Mu, Z X]]
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[[Category: Cui S]]
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[[Category: Atpase]]
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[[Category: Gao X]]
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[[Category: Hexamer]]
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[[Category: Mu Z]]
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[[Category: Hydrolase]]
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[[Category: Structure and function]]
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[[Category: T3ss]]
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Current revision

Structural of the highly conserved ATPase from type III secretion system of bacterial pathogens

PDB ID 5ybh

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