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6b8e

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==Multiconformer model of apo WT PTP1B with glycerol at 180 K==
==Multiconformer model of apo WT PTP1B with glycerol at 180 K==
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<StructureSection load='6b8e' size='340' side='right' caption='[[6b8e]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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<StructureSection load='6b8e' size='340' side='right'caption='[[6b8e]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6b8e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B8E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6b8e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B8E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b8e OCA], [http://pdbe.org/6b8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b8e RCSB], [http://www.ebi.ac.uk/pdbsum/6b8e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b8e ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b8e OCA], [https://pdbe.org/6b8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b8e RCSB], [https://www.ebi.ac.uk/pdbsum/6b8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b8e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Homo sapiens]]
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[[Category: Biel, J T]]
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[[Category: Large Structures]]
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[[Category: Brandao-Neto, J]]
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[[Category: Biel JT]]
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[[Category: Delft, F von]]
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[[Category: Brandao-Neto J]]
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[[Category: Fraser, J S]]
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[[Category: Fraser JS]]
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[[Category: Hill, Z B]]
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[[Category: Hill ZB]]
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[[Category: Kang, E]]
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[[Category: Kang E]]
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[[Category: Keedy, D A]]
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[[Category: Keedy DA]]
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[[Category: Rettenmaier, T J]]
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[[Category: Rettenmaier TJ]]
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[[Category: Wells, J A]]
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[[Category: Wells JA]]
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[[Category: Allostery]]
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[[Category: Von Delft F]]
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[[Category: Enzyme]]
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[[Category: Hydrolase]]
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[[Category: Multiconformer]]
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[[Category: Multitemperature]]
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[[Category: Protein tyrosine phosphatase]]
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[[Category: Protein tyrosine phosphatase 1b]]
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[[Category: Ptp]]
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[[Category: Ptp1b]]
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Current revision

Multiconformer model of apo WT PTP1B with glycerol at 180 K

PDB ID 6b8e

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