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6bv7

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==NMR structure of Sodium/Calcium Exchanger 1 (NCX1) Two-helix Bundle (THB) domain==
==NMR structure of Sodium/Calcium Exchanger 1 (NCX1) Two-helix Bundle (THB) domain==
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<StructureSection load='6bv7' size='340' side='right' caption='[[6bv7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='6bv7' size='340' side='right'caption='[[6bv7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bv7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BV7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BV7 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bv7 OCA], [http://pdbe.org/6bv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bv7 RCSB], [http://www.ebi.ac.uk/pdbsum/6bv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bv7 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bv7 OCA], [https://pdbe.org/6bv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bv7 RCSB], [https://www.ebi.ac.uk/pdbsum/6bv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bv7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NAC1_CANLF NAC1_CANLF]] Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1700476, PubMed:1785844, PubMed:9486131, PubMed:17962412). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions (By similarity).[UniProtKB:P70414]<ref>PMID:1700476</ref> <ref>PMID:1785844</ref> <ref>PMID:17962412</ref> <ref>PMID:19332552</ref> <ref>PMID:9486131</ref>
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[https://www.uniprot.org/uniprot/NAC1_CANLF NAC1_CANLF] Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1700476, PubMed:1785844, PubMed:9486131, PubMed:17962412). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions (By similarity).[UniProtKB:P70414]<ref>PMID:1700476</ref> <ref>PMID:1785844</ref> <ref>PMID:17962412</ref> <ref>PMID:19332552</ref> <ref>PMID:9486131</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bruschweiler, R]]
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[[Category: Canis lupus familiaris]]
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[[Category: Yuan, C]]
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[[Category: Large Structures]]
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[[Category: Yuan, J]]
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[[Category: Bruschweiler R]]
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[[Category: Membrane protein]]
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[[Category: Yuan C]]
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[[Category: Two-helix bundle]]
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[[Category: Yuan J]]

Current revision

NMR structure of Sodium/Calcium Exchanger 1 (NCX1) Two-helix Bundle (THB) domain

PDB ID 6bv7

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