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6c08

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==Zebrafish SLC38A9 with arginine bound in the cytosol open state==
==Zebrafish SLC38A9 with arginine bound in the cytosol open state==
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<StructureSection load='6c08' size='340' side='right' caption='[[6c08]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
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<StructureSection load='6c08' size='340' side='right'caption='[[6c08]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6c08]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C08 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6c08]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C08 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.17&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c08 OCA], [http://pdbe.org/6c08 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c08 RCSB], [http://www.ebi.ac.uk/pdbsum/6c08 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c08 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c08 OCA], [https://pdbe.org/6c08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c08 RCSB], [https://www.ebi.ac.uk/pdbsum/6c08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c08 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/S38A9_DANRE S38A9_DANRE]] Lysosomal amino acid transporter involved in the control of mTORC1 activity in response to amino acids. Probably acts as a amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Mediates transport of amino acids with low capacity, suggesting that it acts as an amino acid sensor instead.[UniProtKB:Q8NBW4]
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[https://www.uniprot.org/uniprot/S38A9_DANRE S38A9_DANRE] Lysosomal amino acid transporter involved in the control of mTORC1 activity in response to amino acids. Probably acts as a amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Mediates transport of amino acids with low capacity, suggesting that it acts as an amino acid sensor instead.[UniProtKB:Q8NBW4]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6c08" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6c08" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Danio rerio]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Gonen, T]]
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[[Category: Gonen T]]
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[[Category: Lei, H T]]
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[[Category: Lei H-T]]
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[[Category: Complex]]
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[[Category: Conformational state]]
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[[Category: Membrane protein]]
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[[Category: Substrate binding]]
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[[Category: Transporter]]
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Current revision

Zebrafish SLC38A9 with arginine bound in the cytosol open state

PDB ID 6c08

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