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2jis

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[[Image:2jis.jpg|left|200px]]
 
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{{Structure
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==Human cysteine sulfinic acid decarboxylase (CSAD) in complex with PLP.==
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|PDB= 2jis |SIZE=350|CAPTION= <scene name='initialview01'>2jis</scene>, resolution 1.60&Aring;
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<StructureSection load='2jis' size='340' side='right'caption='[[2jis]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:No3+Binding+Site+For+Chain+B'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>
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<table><tr><td colspan='2'>[[2jis]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JIS FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfinoalanine_decarboxylase Sulfinoalanine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.29 4.1.1.29] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jis OCA], [https://pdbe.org/2jis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jis RCSB], [https://www.ebi.ac.uk/pdbsum/2jis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jis ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jis OCA], [http://www.ebi.ac.uk/pdbsum/2jis PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jis RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CSAD_HUMAN CSAD_HUMAN] Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate.[UniProtKB:Q9DBE0]
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== Evolutionary Conservation ==
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'''HUMAN CYSTEINE SULFINIC ACID DECARBOXYLASE (CSAD) IN COMPLEX WITH PLP.'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2jis_consurf.spt"</scriptWhenChecked>
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2JIS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIS OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jis ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Sulfinoalanine decarboxylase]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Berglund H]]
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[[Category: Berg, S Van Den.]]
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[[Category: Busam R]]
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[[Category: Berglund, H.]]
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[[Category: Collins R]]
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[[Category: Busam, R.]]
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[[Category: Dahlgren LG]]
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[[Category: Collins, R.]]
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[[Category: Edwards A]]
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[[Category: Dahlgren, L G.]]
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[[Category: Flodin S]]
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[[Category: Edwards, A.]]
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[[Category: Flores A]]
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[[Category: Flodin, S.]]
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[[Category: Graslund S]]
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[[Category: Flores, A.]]
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[[Category: Hallberg BM]]
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[[Category: Graslund, S.]]
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[[Category: Hammarstrom M]]
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[[Category: Hallberg, B M.]]
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[[Category: Holmberg-Schiavone L]]
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[[Category: Hammarstrom, M.]]
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[[Category: Johansson I]]
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[[Category: Holmberg-Schiavone, L.]]
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[[Category: Kallas A]]
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[[Category: Johansson, I.]]
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[[Category: Karlberg T]]
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[[Category: Kallas, A.]]
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[[Category: Kotenyova T]]
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[[Category: Karlberg, T.]]
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[[Category: Lehtio L]]
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[[Category: Kotenyova, T.]]
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[[Category: Moche M]]
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[[Category: Lehtio, L.]]
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[[Category: Nordlund P]]
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[[Category: Moche, M.]]
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[[Category: Nyman T]]
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[[Category: Nordlund, P.]]
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[[Category: Ogg D]]
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[[Category: Nyman, T.]]
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[[Category: Persson C]]
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[[Category: Ogg, D.]]
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[[Category: Sagemark J]]
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[[Category: Persson, C.]]
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[[Category: Stenmark P]]
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[[Category: Sagemark, J.]]
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[[Category: Sundstrom M]]
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[[Category: Sgc, Structural GenomicsConsortium.]]
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[[Category: Thorsell AG]]
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[[Category: Stenmark, P.]]
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[[Category: Tresaugues L]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Thorsell, A G.]]
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[[Category: Welin M]]
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[[Category: Tresaugues, L.]]
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[[Category: Van den Berg S]]
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[[Category: Weigelt, J.]]
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[[Category: Welin, M.]]
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[[Category: alternative splicing]]
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[[Category: decarboxylase]]
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[[Category: lyase]]
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[[Category: pyridoxal phosphate]]
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[[Category: pyridoxal phosphate (plp)]]
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[[Category: structural genomics consortium (sgc)]]
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[[Category: vitamin b6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:58:55 2008''
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Current revision

Human cysteine sulfinic acid decarboxylase (CSAD) in complex with PLP.

PDB ID 2jis

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