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2whz

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==Dipeptide Inhibitors of Thermolysin==
==Dipeptide Inhibitors of Thermolysin==
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<StructureSection load='2whz' size='340' side='right' caption='[[2whz]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='2whz' size='340' side='right'caption='[[2whz]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2whz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/'bacillus_thermoproteolyticus' 'bacillus thermoproteolyticus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WHZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2whz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WHZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TYR:TYROSINE'>TYR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lna|1lna]], [[1pe5|1pe5]], [[1lne|1lne]], [[1hyt|1hyt]], [[1os0|1os0]], [[2tlx|2tlx]], [[1kkk|1kkk]], [[1fjq|1fjq]], [[1fj3|1fj3]], [[1fjt|1fjt]], [[1ks7|1ks7]], [[5tli|5tli]], [[1pe7|1pe7]], [[8tln|8tln]], [[1kei|1kei]], [[2a7g|2a7g]], [[4tmn|4tmn]], [[3tli|3tli]], [[1fjv|1fjv]], [[1lnb|1lnb]], [[1tlx|1tlx]], [[1fjw|1fjw]], [[1kjo|1kjo]], [[2wi0|2wi0]], [[1fju|1fju]], [[1kro|1kro]], [[1fjo|1fjo]], [[1tli|1tli]], [[3tmn|3tmn]], [[6tmn|6tmn]], [[1lnd|1lnd]], [[1thl|1thl]], [[7tln|7tln]], [[7tli|7tli]], [[1lnf|1lnf]], [[8tli|8tli]], [[1z9g|1z9g]], [[1y3g|1y3g]], [[1kjp|1kjp]], [[1kr6|1kr6]], [[1qf0|1qf0]], [[1pe8|1pe8]], [[1kl6|1kl6]], [[5tln|5tln]], [[4tli|4tli]], [[6tli|6tli]], [[4tln|4tln]], [[5tmn|5tmn]], [[2tmn|2tmn]], [[1lnc|1lnc]], [[1kto|1kto]], [[1qf2|1qf2]], [[1trl|1trl]], [[1tmn|1tmn]], [[1l3f|1l3f]], [[1gxw|1gxw]], [[2tli|2tli]], [[1zdp|1zdp]], [[1tlp|1tlp]], [[1qf1|1qf1]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TYR:TYROSINE'>TYR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2whz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whz OCA], [https://pdbe.org/2whz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2whz RCSB], [https://www.ebi.ac.uk/pdbsum/2whz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2whz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2whz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whz OCA], [http://pdbe.org/2whz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2whz RCSB], [http://www.ebi.ac.uk/pdbsum/2whz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2whz ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/THER_BACTH THER_BACTH]] Extracellular zinc metalloprotease.
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[https://www.uniprot.org/uniprot/THER_BACTH THER_BACTH] Extracellular zinc metalloprotease.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Thermolysin|Thermolysin]]
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*[[Thermolysin 3D structures|Thermolysin 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus thermoproteolyticus]]
[[Category: Bacillus thermoproteolyticus]]
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[[Category: Thermolysin]]
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[[Category: Large Structures]]
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[[Category: Leiros, H K.S]]
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[[Category: Leiros H-KS]]
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[[Category: Leiros, I]]
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[[Category: Leiros I]]
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[[Category: Lund, B A]]
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[[Category: Lund BA]]
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[[Category: Dipeptide inhibitor]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-inhibitor complex]]
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Current revision

Dipeptide Inhibitors of Thermolysin

PDB ID 2whz

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