2jnz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:08, 20 December 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2jnz.jpg|left|200px]]
 
-
{{Structure
+
==Solution structure of phl p 3, a major allergen from timothy grass pollen==
-
|PDB= 2jnz |SIZE=350|CAPTION= <scene name='initialview01'>2jnz</scene>
+
<StructureSection load='2jnz' size='340' side='right'caption='[[2jnz]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[2jnz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JNZ FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jnz OCA], [https://pdbe.org/2jnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jnz RCSB], [https://www.ebi.ac.uk/pdbsum/2jnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jnz ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jnz OCA], [http://www.ebi.ac.uk/pdbsum/2jnz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jnz RCSB]</span>
+
[https://www.uniprot.org/uniprot/Q69B42_PHLPR Q69B42_PHLPR]
-
}}
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/2jnz_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jnz ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The major 97-aa timothy grass (Phleum pratense) allergen Phl p 3 was recently isolated from an extract of timothy grass pollen. Sequence comparison classifies this protein as a group 3 allergen. The solution structure of Phl p 3 as determined by nuclear magnetic resonance spectroscopy reveals that the protein consists of a core of hydrophobic amino-acid side chains from two beta-sheets of five and four anti-parallel beta-strands, respectively. This conformation is very similar to the crystal structure published for Phl p 2 and strongly resembles the known conformation of the carboxy-terminal domain of Phl p 1, the major difference being the loop orientations. Phl p 2 and Phl p 3 show virtually identical immunoreactivity, and comparison of the charged surface amino acids of the two proteins gives initial clues as to the IgE recognition epitopes of these proteins.
-
'''Solution structure of phl p 3, a major allergen from timothy grass pollen'''
+
Solution structure of Phl p 3, a major allergen from timothy grass pollen.,Schweimer K, Petersen A, Suck R, Becker WM, Rosch P, Matecko I Biol Chem. 2008 Jul;389(7):919-23. PMID:18627309<ref>PMID:18627309</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
==About this Structure==
+
</div>
-
2JNZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Phleum_pratense Phleum pratense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNZ OCA].
+
<div class="pdbe-citations 2jnz" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Phleum pratense]]
[[Category: Phleum pratense]]
-
[[Category: Single protein]]
+
[[Category: Matecko I]]
-
[[Category: Matecko, I.]]
+
[[Category: Roesch P]]
-
[[Category: Roesch, P.]]
+
[[Category: Schweimer K]]
-
[[Category: Schweimer, K.]]
+
-
[[Category: allergen]]
+
-
[[Category: timothy grass pollen]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:59:50 2008''
+

Current revision

Solution structure of phl p 3, a major allergen from timothy grass pollen

PDB ID 2jnz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jnz"
Personal tools