2g2b

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==NMR structure of the human allograft inflammatory factor 1==
==NMR structure of the human allograft inflammatory factor 1==
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<StructureSection load='2g2b' size='340' side='right' caption='[[2g2b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2g2b' size='340' side='right'caption='[[2g2b]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2g2b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G2B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2g2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G2B FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AIF1, G1, IBA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g2b OCA], [http://pdbe.org/2g2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g2b RCSB], [http://www.ebi.ac.uk/pdbsum/2g2b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2g2b ProSAT], [http://www.topsan.org/Proteins/CESG/2g2b TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g2b OCA], [https://pdbe.org/2g2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g2b RCSB], [https://www.ebi.ac.uk/pdbsum/2g2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g2b ProSAT], [https://www.topsan.org/Proteins/CESG/2g2b TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AIF1_HUMAN AIF1_HUMAN]] Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.<ref>PMID:15117732</ref> <ref>PMID:16049345</ref> <ref>PMID:18699778</ref>
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[https://www.uniprot.org/uniprot/AIF1_HUMAN AIF1_HUMAN] Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.<ref>PMID:15117732</ref> <ref>PMID:16049345</ref> <ref>PMID:18699778</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Structural genomic]]
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[[Category: Large Structures]]
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[[Category: Markley, J L]]
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[[Category: Markley JL]]
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[[Category: Newman, C L]]
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[[Category: Newman CL]]
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[[Category: Song, J]]
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[[Category: Song J]]
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[[Category: Tyler, R C]]
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[[Category: Tyler RC]]
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[[Category: Vinarov, D]]
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[[Category: Vinarov D]]
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[[Category: Aif-1]]
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[[Category: Allograft inflammatory factor 1]]
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[[Category: Cesg]]
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[[Category: Immune system]]
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[[Category: PSI, Protein structure initiative]]
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Current revision

NMR structure of the human allograft inflammatory factor 1

PDB ID 2g2b

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