2g0n

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==The Crystal Structure of the Human RAC3 in complex with GDP and Chloride==
==The Crystal Structure of the Human RAC3 in complex with GDP and Chloride==
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<StructureSection load='2g0n' size='340' side='right' caption='[[2g0n]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='2g0n' size='340' side='right'caption='[[2g0n]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2g0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G0N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2g0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G0N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mh1|1mh1]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0n OCA], [https://pdbe.org/2g0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g0n RCSB], [https://www.ebi.ac.uk/pdbsum/2g0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0n OCA], [http://pdbe.org/2g0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g0n RCSB], [http://www.ebi.ac.uk/pdbsum/2g0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0n ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref>
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[https://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Rac|Rac]]
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*[[Rac 3D structures|Rac 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C]]
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[[Category: Large Structures]]
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[[Category: Bunkoczi, G]]
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[[Category: Arrowsmith C]]
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[[Category: Burgess, N]]
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[[Category: Bunkoczi G]]
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[[Category: Colebrook, S]]
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[[Category: Burgess N]]
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[[Category: Delft, F von]]
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[[Category: Colebrook S]]
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[[Category: Doyle, D]]
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[[Category: Doyle D]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Elkins, J]]
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[[Category: Elkins J]]
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[[Category: Fedorov, O]]
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[[Category: Fedorov O]]
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[[Category: Gileadi, C]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, O]]
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[[Category: Gileadi O]]
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[[Category: Structural genomic]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Yang X]]
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[[Category: Yang, X]]
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[[Category: Zao Y]]
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[[Category: Zao, Y]]
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[[Category: Von Delft F]]
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[[Category: Gtpase rac3a]]
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[[Category: P21 rac]]
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[[Category: Ras-related c3 botulinum toxin substrate 3]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Signalling protein]]
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[[Category: Small gtp binding protein]]
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Current revision

The Crystal Structure of the Human RAC3 in complex with GDP and Chloride

PDB ID 2g0n

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Proteopedia Page Contributors and Editors (what is this?)

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