6a4i
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6a4i is ON HOLD Authors: Fu, G., Wang, J., Luo, G., Wu, G., Qian, K. Description: Crystal Structure of human TDO inhibitor complex [[Category: Unre...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of human TDO inhibitor complex== | |
| + | <StructureSection load='6a4i' size='340' side='right'caption='[[6a4i]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6a4i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A4I FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9R9:1-(6-chloro-1H-indazol-4-yl)cyclohexan-1-ol'>9R9</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a4i OCA], [https://pdbe.org/6a4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a4i RCSB], [https://www.ebi.ac.uk/pdbsum/6a4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a4i ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Dioxygenase 3D structures|Dioxygenase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Fu G]] |
| - | [[Category: Qian | + | [[Category: Luo G]] |
| - | [[Category: Wang | + | [[Category: Qian K]] |
| + | [[Category: Wang J]] | ||
| + | [[Category: Wu G]] | ||
Current revision
Crystal Structure of human TDO inhibitor complex
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Categories: Homo sapiens | Large Structures | Fu G | Luo G | Qian K | Wang J | Wu G
