6a4r
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of aspartate bound peptidase E from Salmonella enterica== | |
| + | <StructureSection load='6a4r' size='340' side='right'caption='[[6a4r]], [[Resolution|resolution]] 1.83Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6a4r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A4R FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.828Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a4r OCA], [https://pdbe.org/6a4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a4r RCSB], [https://www.ebi.ac.uk/pdbsum/6a4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a4r ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PEPE_SALTY PEPE_SALTY] Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.[HAMAP-Rule:MF_00510] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Peptidase-E, a nonclassical serine peptidase, is specific for dipeptides with an N-terminal aspartate. This stringent substrate specificity remains largely unexplained. We report an aspartate-bound structure of peptidase-E at 1.83 A resolution. In contrast to previous reports, the enzyme forms a dimer, and the active site is located at the dimer interface, well shielded from the solvent. Our findings further suggest that the stringent aspartate specificity of the enzyme is due to electrostatics and molecular complementarity in the active site. The new structural information presented herein may provide insights into the role of functionally important residues in peptidase-E. | ||
| - | + | Structure of Asp-bound peptidase E from Salmonella enterica: Active site at dimer interface illuminates Asp recognition.,Yadav P, Goyal VD, Gaur NK, Kumar A, Gokhale SM, Makde RD FEBS Lett. 2018 Oct;592(19):3346-3354. doi: 10.1002/1873-3468.13247. Epub 2018, Sep 21. PMID:30194851<ref>PMID:30194851</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6a4r" style="background-color:#fffaf0;"></div> |
| - | [[Category: Gokhale | + | == References == |
| - | [[Category: Goyal | + | <references/> |
| - | [[Category: Kumar | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Singh | + | [[Category: Large Structures]] |
| - | [[Category: Yadav | + | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]] |
| + | [[Category: Chandravanshi K]] | ||
| + | [[Category: Gokhale SM]] | ||
| + | [[Category: Goyal VD]] | ||
| + | [[Category: Kumar A]] | ||
| + | [[Category: Makde RD]] | ||
| + | [[Category: Singh R]] | ||
| + | [[Category: Yadav P]] | ||
Current revision
Crystal structure of aspartate bound peptidase E from Salmonella enterica
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