2jwe

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[[Image:2jwe.gif|left|200px]]
 
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{{Structure
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==Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping==
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|PDB= 2jwe |SIZE=350|CAPTION= <scene name='initialview01'>2jwe</scene>
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<StructureSection load='2jwe' size='340' side='right'caption='[[2jwe]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2jwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JWE FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= TJP1, ZO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwe OCA], [https://pdbe.org/2jwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jwe RCSB], [https://www.ebi.ac.uk/pdbsum/2jwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwe ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwe OCA], [http://www.ebi.ac.uk/pdbsum/2jwe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jwe RCSB]</span>
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[https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/2jwe_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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2JWE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWE OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jwe ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ji, P.]]
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[[Category: Ji P]]
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[[Category: Shi, Y Y.]]
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[[Category: Shi YY]]
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[[Category: Wu, J H.]]
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[[Category: Wu JH]]
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[[Category: Wu, J W.]]
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[[Category: Wu JW]]
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[[Category: Yang, Y S.]]
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[[Category: Yang YS]]
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[[Category: Zhang, J H.]]
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[[Category: Zhang JH]]
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[[Category: alternative splicing]]
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[[Category: cell adhesion]]
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[[Category: cell junction]]
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[[Category: dimer]]
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[[Category: domain swapping]]
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[[Category: membrane]]
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[[Category: phosphorylation]]
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[[Category: polymorphism]]
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[[Category: sh3 domain]]
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[[Category: tight junction]]
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[[Category: tjp1]]
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[[Category: zo-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:02:10 2008''
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Current revision

Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping

PDB ID 2jwe

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