2jxc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:43, 1 May 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2jxc.jpg|left|200px]]
 
-
{{Structure
+
==Structure of the EPS15-EH2 Stonin2 Complex==
-
|PDB= 2jxc |SIZE=350|CAPTION= <scene name='initialview01'>2jxc</scene>
+
<StructureSection load='2jxc' size='340' side='right'caption='[[2jxc]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
+
<table><tr><td colspan='2'>[[2jxc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXC FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE= EPS15, AF1P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), STON2, STN2, STNB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxc OCA], [https://pdbe.org/2jxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxc RCSB], [https://www.ebi.ac.uk/pdbsum/2jxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxc ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[1eh2|1eh2]], [[1ff1|1ff1]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxc OCA], [http://www.ebi.ac.uk/pdbsum/2jxc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jxc RCSB]</span>
+
== Disease ==
-
}}
+
[https://www.uniprot.org/uniprot/EPS15_HUMAN EPS15_HUMAN] Note=A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with MLL/HRX. The result is a rogue activator protein.
-
 
+
== Function ==
-
'''Structure of the EPS15-EH2 Stonin2 Complex'''
+
[https://www.uniprot.org/uniprot/EPS15_HUMAN EPS15_HUMAN] Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.<ref>PMID:18362181</ref> <ref>PMID:19458185</ref> <ref>PMID:22648170</ref> <ref>PMID:16903783</ref>
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
==About this Structure==
+
Check<jmol>
-
2JXC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXC OCA].
+
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxc_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jxc ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Groemping, Y.]]
+
[[Category: Groemping Y]]
-
[[Category: Haucke, V.]]
+
[[Category: Haucke V]]
-
[[Category: Jung, N.]]
+
[[Category: Jung N]]
-
[[Category: Maritzen, T.]]
+
[[Category: Maritzen T]]
-
[[Category: Rumpf, J.]]
+
[[Category: Rumpf J]]
-
[[Category: Sattler, M.]]
+
[[Category: Sattler M]]
-
[[Category: Simon, B.]]
+
[[Category: Simon B]]
-
[[Category: alternative splicing]]
+
-
[[Category: calcium]]
+
-
[[Category: chromosomal rearrangement]]
+
-
[[Category: cytoplasm]]
+
-
[[Category: endocytosis]]
+
-
[[Category: endocytosis/protein binding complex]]
+
-
[[Category: membrane]]
+
-
[[Category: phosphorylation]]
+
-
[[Category: polymorphism]]
+
-
[[Category: proto-oncogene]]
+
-
[[Category: sh3-binding]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:02:22 2008''
+

Current revision

Structure of the EPS15-EH2 Stonin2 Complex

PDB ID 2jxc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jxc"
Personal tools