6dt3
From Proteopedia
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==1.2 Angstrom Resolution Crystal Structure of Nucleoside Triphosphatase NudI from Klebsiella pneumoniae in Complex with HEPES== | ==1.2 Angstrom Resolution Crystal Structure of Nucleoside Triphosphatase NudI from Klebsiella pneumoniae in Complex with HEPES== | ||
| - | <StructureSection load='6dt3' size='340' side='right' caption='[[6dt3]], [[Resolution|resolution]] 1.20Å' scene=''> | + | <StructureSection load='6dt3' size='340' side='right'caption='[[6dt3]], [[Resolution|resolution]] 1.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6dt3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT3 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6dt3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae_NTUH-K2044 Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DT3 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dt3 OCA], [https://pdbe.org/6dt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dt3 RCSB], [https://www.ebi.ac.uk/pdbsum/6dt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dt3 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/A0A1W1Q5B1_KLEPN A0A1W1Q5B1_KLEPN] Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).[HAMAP-Rule:MF_01846] |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Klebsiella pneumoniae is a leading cause of antibiotic-resistant-associated deaths in the world. Here, we report the deposition of 14 structures of enzymes from both the core and accessory genomes of sequence type 23 (ST23) K1 hypervirulent K. pneumoniae. | ||
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| + | A Structural Systems Biology Approach to High-Risk CG23 Klebsiella pneumoniae.,Inniss NL, Kochan TJ, Minasov G, Wawrzak Z, Chang C, Tan K, Shuvalova L, Kiryukhina O, Pshenychnyi S, Wu R, Dubrovska I, Babnigg G, Endres M, Anderson WF, Hauser AR, Joachimiak A, Satchell KJF Microbiol Resour Announc. 2023 Feb 16;12(2):e0101322. doi: 10.1128/mra.01013-22. , Epub 2023 Jan 25. PMID:36695589<ref>PMID:36695589</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6dt3" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Nucleoside triphosphatase|Nucleoside triphosphatase]] | ||
| + | *[[Sandbox 30008|Sandbox 30008]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]] |
| - | [[Category: Endres | + | [[Category: Large Structures]] |
| - | [[Category: Joachimiak | + | [[Category: Endres M]] |
| - | [[Category: Minasov | + | [[Category: Joachimiak A]] |
| - | [[Category: Pshenychnyi | + | [[Category: Minasov G]] |
| - | [[Category: Satchell | + | [[Category: Pshenychnyi S]] |
| - | [[Category: Shuvalova | + | [[Category: Satchell KJF]] |
| - | + | [[Category: Shuvalova L]] | |
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Current revision
1.2 Angstrom Resolution Crystal Structure of Nucleoside Triphosphatase NudI from Klebsiella pneumoniae in Complex with HEPES
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