2he7

<StructureSection load='2he7' size='340' side='right' caption='[[2he7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[2he7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HE7 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EPB41L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2he7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2he7 OCA], [http://pdbe.org/2he7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2he7 RCSB], [http://www.ebi.ac.uk/pdbsum/2he7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2he7 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/E41L3_HUMAN E41L3_HUMAN]] Critical growth regulator in the pathogenesis of meningiomas.

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== Publication Abstract from PubMed ==

Perturbed cell-adhesion mechanisms are crucial for tumor invasion and metastasis. A cell-adhesion protein, Tumor Suppressor in Lung Cancer 1 (TSLC1), is inactivated in a majority of metastatic cancers. DAL-1 (differentially expressed in adenocarcinoma of the lung protein), another tumor suppressor, binds through its FERM domain to the TSLC1 C-terminal, 4.1 glycophorin C-like, cytoplasmic domain. However, the molecular basis for this interaction is unknown. Here, we describe the crystal structure of a complex between the DAL-1 FERM domain and a portion of the TSLC1 cytoplasmic domain. DAL-1 binds to TSLC1 through conserved residues in a well-defined hydrophobic pocket in the DAL-1 FERM domain's structural C-lobe. From the crystal structure, it is apparent that Tyr406 and Thr408 in the TSLC1 cytoplasmic domain form the most important interactions with DAL-1 and this was also confirmed by surface plasmon resonance studies. Our results refute earlier exon deletion experiments that indicated that glycophorin-C interacts with the alpha-lobe of 4.1 FERM domains.

Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B).,Busam RD, Thorsell AG, Flores A, Hammarstrom M, Persson C, Obrink B, Hallberg BM J Biol Chem. 2010 Dec 3. PMID:21131357<ref>PMID:21131357</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2he7" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Human]]

[[Category: Arrowsmith, C]]

[[Category: Berglund, H]]

[[Category: Busam, R D]]

[[Category: Collins, R]]

[[Category: Edwards, A]]

[[Category: Ehn, M]]

[[Category: Flodin, S]]

[[Category: Flores, A]]

[[Category: Graslund, S]]

[[Category: Hallberg, B M]]

[[Category: Hammarstrom, M]]

[[Category: Hogbom, M]]

[[Category: Johansson, I]]

[[Category: Karlberg, T]]

[[Category: Kotenyova, T]]

[[Category: Nilsson-ehle, P]]

[[Category: Nilvebrandt, J]]

[[Category: Norberg, P]]

[[Category: Nordlund, P]]

[[Category: Nyman, T]]

[[Category: Ogg, D]]

[[Category: Persson, C]]

[[Category: Structural genomic]]

[[Category: Sagemark, J]]

[[Category: Schiavone, L H]]

[[Category: Stenmark, P]]

[[Category: Sundstrom, M]]

[[Category: Thorsell, A G]]

[[Category: Uppenberg, J]]

[[Category: Weigelt, J]]

[[Category: Berg, S Van den]]

[[Category: Cell adhesion]]

[[Category: Sgc]]