2gxa

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==Crystal structure of papillomavirus E1 hexameric helicase with ssDNA and MgADP==
==Crystal structure of papillomavirus E1 hexameric helicase with ssDNA and MgADP==
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<StructureSection load='2gxa' size='340' side='right' caption='[[2gxa]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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<StructureSection load='2gxa' size='340' side='right'caption='[[2gxa]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2gxa]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GXA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2gxa]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Deltapapillomavirus_4 Deltapapillomavirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GXA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gxa OCA], [http://pdbe.org/2gxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gxa RCSB], [http://www.ebi.ac.uk/pdbsum/2gxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gxa ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gxa OCA], [https://pdbe.org/2gxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gxa RCSB], [https://www.ebi.ac.uk/pdbsum/2gxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gxa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VE1_BPV1 VE1_BPV1]] ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.
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[https://www.uniprot.org/uniprot/VE1_BPV1 VE1_BPV1] ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Helicase|Helicase]]
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*[[Helicase 3D structures|Helicase 3D structures]]
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*[[Replication protein E1|Replication protein E1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Enemark, E J]]
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[[Category: Deltapapillomavirus 4]]
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[[Category: Joshua-Tor, L]]
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[[Category: Large Structures]]
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[[Category: Aaa+]]
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[[Category: Enemark EJ]]
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[[Category: Atpase]]
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[[Category: Joshua-Tor L]]
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[[Category: Dna helicase]]
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[[Category: Initiator protein]]
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[[Category: Replication]]
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[[Category: Replication-dna complex]]
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[[Category: Virus]]
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Current revision

Crystal structure of papillomavirus E1 hexameric helicase with ssDNA and MgADP

PDB ID 2gxa

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