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6dmi
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==A multiconformer ligand model of 5T5 bound to BACE-1== | |
| + | <StructureSection load='6dmi' size='340' side='right'caption='[[6dmi]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6dmi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DMI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5T5:[(1~{R},2~{R})-2-[(4~{S})-2-AZANYL-4-[4-[BIS(FLUORANYL)METHOXY]PHENYL]-5~{H}-1,3-OXAZOL-4-YL]CYCLOPROPYL]-(5-CHLORANYLPYRIDIN-3-YL)METHANONE'>5T5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dmi OCA], [https://pdbe.org/6dmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dmi RCSB], [https://www.ebi.ac.uk/pdbsum/6dmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dmi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Borrelli K]] | ||
| + | [[Category: Day T]] | ||
| + | [[Category: Fonseca R]] | ||
| + | [[Category: Fraser JS]] | ||
| + | [[Category: Heliou A]] | ||
| + | [[Category: Hudson BM]] | ||
| + | [[Category: Keedy D]] | ||
| + | [[Category: Suresh P]] | ||
| + | [[Category: Van Zundert G]] | ||
| + | [[Category: Van den Bedem H]] | ||
Current revision
A multiconformer ligand model of 5T5 bound to BACE-1
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Categories: Homo sapiens | Large Structures | Borrelli K | Day T | Fonseca R | Fraser JS | Heliou A | Hudson BM | Keedy D | Suresh P | Van Zundert G | Van den Bedem H
