5ysm

<StructureSection load='5ysm' size='340' side='right' caption='[[5ysm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[5ysm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YSM FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ysm OCA], [http://pdbe.org/5ysm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ysm RCSB], [http://www.ebi.ac.uk/pdbsum/5ysm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ysm ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Rifamycin-derived drugs, including rifampin, rifabutin, rifapentine, and rifaximin, have long been used as first-line therapies for the treatment of tuberculosis and other deadly infections. However, the late steps leading to the biosynthesis of the industrially important rifamycin SV and B remain largely unknown. Here, we characterize a network of reactions underlying the biosynthesis of rifamycin SV, S, L, O, and B. The two-subunit transketolase Rif15 and the cytochrome P450 enzyme Rif16 are found to mediate, respectively, a unique C-O bond formation in rifamycin L and an atypical P450 ester-to-ether transformation from rifamycin L to B. Both reactions showcase interesting chemistries for these two widespread and well-studied enzyme families.

 

== References ==

[[Category: Li, F W]]

[[Category: Li, S Y]]

[[Category: Qi, F F]]

[[Category: Xiao, Y L]]

[[Category: Zhao, G P]]

[[Category: Cytochrome p450]]

[[Category: Metal binding protein]]

[[Category: Rifamycin]]