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6dd3
From Proteopedia
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==Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state== | ==Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state== | ||
| - | <StructureSection load='6dd3' size='340' side='right' caption='[[6dd3]], [[Resolution|resolution]] 1.98Å' scene=''> | + | <StructureSection load='6dd3' size='340' side='right'caption='[[6dd3]], [[Resolution|resolution]] 1.98Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6dd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DD3 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dd3 OCA], [https://pdbe.org/6dd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dd3 RCSB], [https://www.ebi.ac.uk/pdbsum/6dd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dd3 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref> |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Ambesi-Impiombato | + | [[Category: Large Structures]] |
| - | [[Category: Carpenter | + | [[Category: Ambesi-Impiombato A]] |
| - | [[Category: Dieck | + | [[Category: Carpenter Z]] |
| - | [[Category: Ferrando | + | [[Category: Dieck CL]] |
| - | [[Category: Forouhar | + | [[Category: Ferrando AA]] |
| - | [[Category: Kirschner-Schwabe | + | [[Category: Forouhar F]] |
| - | [[Category: Lew | + | [[Category: Kirschner-Schwabe R]] |
| - | [[Category: Sanchez-Martin | + | [[Category: Lew S]] |
| - | [[Category: Seetharaman | + | [[Category: Sanchez-Martin M]] |
| - | [[Category: Tong | + | [[Category: Seetharaman J]] |
| - | [[Category: Tzoneva | + | [[Category: Tong L]] |
| - | + | [[Category: Tzoneva G]] | |
Current revision
Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state
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