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6f62

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==Crystal structure of the SYCP1 N-terminal head-to-head assembly in open conformation==
==Crystal structure of the SYCP1 N-terminal head-to-head assembly in open conformation==
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<StructureSection load='6f62' size='340' side='right' caption='[[6f62]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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<StructureSection load='6f62' size='340' side='right'caption='[[6f62]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6f62]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F62 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6f62]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6F62 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.066&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6f5x|6f5x]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SYCP1, SCP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6f62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f62 OCA], [https://pdbe.org/6f62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6f62 RCSB], [https://www.ebi.ac.uk/pdbsum/6f62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6f62 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f62 OCA], [http://pdbe.org/6f62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f62 RCSB], [http://www.ebi.ac.uk/pdbsum/6f62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f62 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SYCP1_HUMAN SYCP1_HUMAN]] Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility.[UniProtKB:Q62209]
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[https://www.uniprot.org/uniprot/SYCP1_HUMAN SYCP1_HUMAN] Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility.[UniProtKB:Q62209]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Davies, O R]]
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[[Category: Large Structures]]
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[[Category: Dunce, J M]]
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[[Category: Davies OR]]
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[[Category: Chromosome structure]]
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[[Category: Dunce JM]]
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[[Category: Coiled-coil]]
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[[Category: Meiosis]]
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[[Category: Self-assembly]]
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[[Category: Structural protein]]
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Current revision

Crystal structure of the SYCP1 N-terminal head-to-head assembly in open conformation

PDB ID 6f62

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