2i39

<StructureSection load='2i39' size='340' side='right' caption='[[2i39]], [[Resolution|resolution]] 2.20&Aring;' scene=''>

<table><tr><td colspan='2'>[[2i39]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I39 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">N1L (VACWR028) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10245 Vaccinia virus])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i39 OCA], [http://pdbe.org/2i39 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i39 RCSB], [http://www.ebi.ac.uk/pdbsum/2i39 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i39 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/N1_VACCC N1_VACCC]] Bcl-2-like protein which contributes to virulence by preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B.

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== Publication Abstract from PubMed ==

Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein.,Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:17123957<ref>PMID:17123957</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2i39" style="background-color:#fffaf0;"></div>

*[[B-cell lymphoma protein|B-cell lymphoma protein]]

[[Category: Aleshin, A E]]

[[Category: Aoyagi, M]]

[[Category: Liddington, R C]]

[[Category: Stec, B]]

[[Category: Viral protein]]