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2int
From Proteopedia
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==CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4== | ==CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4== | ||
| - | <StructureSection load='2int' size='340' side='right' caption='[[2int]], [[Resolution|resolution]] 2.35Å' scene=''> | + | <StructureSection load='2int' size='340' side='right'caption='[[2int]], [[Resolution|resolution]] 2.35Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2int]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2int]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2INT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2INT FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2int FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2int OCA], [https://pdbe.org/2int PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2int RCSB], [https://www.ebi.ac.uk/pdbsum/2int PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2int ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[https://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:14681304</ref> |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Interleukin|Interleukin]] | + | *[[Interleukin 3D structures|Interleukin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Bugg, C E]] | [[Category: Bugg, C E]] | ||
[[Category: Cook, W J]] | [[Category: Cook, W J]] | ||
Current revision
CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4
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