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2ipx

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==Human Fibrillarin==
==Human Fibrillarin==
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<StructureSection load='2ipx' size='340' side='right' caption='[[2ipx]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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<StructureSection load='2ipx' size='340' side='right'caption='[[2ipx]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IPX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ipx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IPX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FBL, FIB1, FLRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipx OCA], [https://pdbe.org/2ipx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ipx RCSB], [https://www.ebi.ac.uk/pdbsum/2ipx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ipx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipx OCA], [http://pdbe.org/2ipx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ipx RCSB], [http://www.ebi.ac.uk/pdbsum/2ipx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ipx ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FBRL_HUMAN FBRL_HUMAN]] Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
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[https://www.uniprot.org/uniprot/FBRL_HUMAN FBRL_HUMAN] Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M]]
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[[Category: Bochkarev A]]
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[[Category: Loppnau, P]]
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[[Category: Edwards AM]]
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[[Category: Min, J]]
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[[Category: Loppnau P]]
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[[Category: Plotnikov, A N]]
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[[Category: Min J]]
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[[Category: Structural genomic]]
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[[Category: Plotnikov AN]]
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[[Category: Sundstrom, M]]
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[[Category: Sundstrom M]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Wu, H]]
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[[Category: Wu H]]
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[[Category: Zeng, H]]
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[[Category: Zeng H]]
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[[Category: Fbl]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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Current revision

Human Fibrillarin

PDB ID 2ipx

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