6gz6
From Proteopedia
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(New page: '''Unreleased structure''' The entry 6gz6 is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of a left-handed G-quadruplex== | |
| + | <StructureSection load='6gz6' size='340' side='right'caption='[[6gz6]], [[Resolution|resolution]] 2.01Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6gz6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GZ6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gz6 OCA], [http://pdbe.org/6gz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gz6 RCSB], [http://www.ebi.ac.uk/pdbsum/6gz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gz6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Recently, we observed the first example of a left-handed G-quadruplex structure formed by natural DNA, named Z-G4. We analysed the Z-G4 structure and inspected its primary 28-nt sequence in order to identify motifs that convey the unique left-handed twist. Using CD, NMR spectroscopy and X-ray crystallography, we revealed a minimal sequence motif of 12 nt GTGGTGGTGGTG for the left-handed DNA G-quadruplex formation, which is found to be highly abundant in the human genome. A systematic analysis of thymine loop mutations revealed a moderate sequence tolerance, which would further broaden the space of sequences prone to left-handed G-quadruplex formation. | ||
| - | + | A minimal sequence for left-handed G-quadruplex formation.,Phan AT Angew Chem Int Ed Engl. 2018 Nov 27. doi: 10.1002/anie.201812628. PMID:30481397<ref>PMID:30481397</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6gz6" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bakalar, B]] | ||
| + | [[Category: Heddi, B]] | ||
| + | [[Category: Mechulam, Y]] | ||
| + | [[Category: Phan, A T]] | ||
| + | [[Category: Schmitt, E]] | ||
| + | [[Category: Dna]] | ||
| + | [[Category: G-quadruplex]] | ||
Current revision
Structure of a left-handed G-quadruplex
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Categories: Large Structures | Bakalar, B | Heddi, B | Mechulam, Y | Phan, A T | Schmitt, E | Dna | G-quadruplex
